The syntheses of N-substituted 3-aminothiophenes have been investigated. These were prepared by the application of the Hofmann hypobromite rearrangement procedure to 3- thenamide, followed by reaction with the appropriate acid chloride or anhydride. It is significant that 2-thenamide fails to undergo the Hofmann rearrangement while 3-thenamide gives high yields of the corresponding amine under the conditions used. Several N- ...
