Tetrahedron

Addition of diethylzinc to aryl aldehydes catalyzed by (1S, 3S)-N, N 1-bis [benzyl]-1, 3-diphenyl-1, 3-propanediamine and its dilithium salt: a mechanistic rationale …

D Pini, A Mastantuono, G Uccello-Barretta, A Iuliano…

文献索引：Pini, Dario; Mastantuono, Alberto; Uccello-Barretta, Gloria; Iuliano, Anna; Salvadori, Piero Tetrahedron, 1993 , vol. 49, # 42 p. 9613 - 9624

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被引用次数: 46

摘要

N, NI-bis-benzyl substituted 1, 3-diamine 1a, synthesized in high optical purity, and the corresponding dilithium salt 1b are used, for the first time, as chiral catalysts in the addition of ZnEt2 to aromatic aldehydes. Both 1a and 1b are able to promote the reaction but the products obtained exhibited low enantiomeric excesses. By 1H NMR and UV-CD investigation, experimental evidences about the structure of some reaction intermediates ...