The preparation of a series of novel chromone-fused cytosine analogues, ie, chromeno [2, 3- d] pyrimidines has been carried out from substituted 2-amino-4-oxo-4H-chromene-3- carbonitriles with urea, thiourea, and guanidine under different reaction conditions. These chromone-fused cytosine analogues were evaluated for their in vitro activity against Mycobacterium tuberculosis H37Rv strain and different microbial pathogenic strains in cell ...
