Anti-Neoplastic Activity of 1, 3-Diaza-2-Functionalized-Adamantan-6-One Compounds Against Melanoma Cells

…, S Levinger, M Ben-Dahan Lellouche…

文献索引：Sharabi-Ronen, Yifat; Levinger, Shlomo; Lellouche, Miri Ben-Dahan; Albeck, Amnon Medicinal Chemistry, 2014 , vol. 10, # 1 p. 27 - 37

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摘要

Four series of 1, 3-diaza-2-functionalized-adamantan-6-one derivatives, bearing at the 2 position SO, SO2, POCl and PO2H functional groups, were synthesized via a key quadruple Mannich reaction, followed by transformation of an aminal functionality into the final 2-thia- and 2-phospha compounds. The compounds were tested for cytotoxic activity against the mouse B16-F10 melanoma cell line. Malignant melanoma is notorious for its high ...