Summary: An effective sequence for the synthesis of a, P-unsaturated ketones involves (1) the Horner-Emmons modification of the Wittig reaction to synthesize a,@-unsaturated nitriles, RzCH2 (Rl) C= C (R3) CN, from carbonyl compounds, R2CH2COR1, and (2) the oxidative decyanation of the a,@-unsaturated nitriles to afford a,@-unsaturated ketones, R2CH= C (Rl) COR3, by sequential treatment with lithium diisopropylamide, oxygen gas, ...
