Characterization of a CNS penetrant, selective M1 muscarinic receptor agonist, 77??LH??28??1

…, A Teriakidis, MD Wood, M Whittington…

文献索引：Langmead; Austin; Branch; Brown; Buchanan; Davies; Forbes; Fry; Hagan; Herdon; Jones; Jeggo; Kew; Mazzali; Melarange; Patel; Pardoe; Randall; Roberts; Roopun; Starr; Teriakidis; Wood; Whittington; Wu; Watson British Journal of Pharmacology, 2008 , vol. 154, # 5 p. 1104 - 1115

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被引用次数: 66

摘要

Background and purpose: M 1 muscarinic ACh receptors (mAChRs) represent an attractive drug target for the treatment of cognitive deficits associated with diseases such as Alzheimer's disease and schizophrenia. However, the discovery of subtype-selective ...