Achieving multi-isoform PI3K inhibition in a series of substituted 3, 4-dihydro-2H-benzo [1, 4] oxazines

…, R Alexander, G Bennett, G Buckley, T Ceska…

文献索引：Perry, Benjamin; Alexander, Rikki; Bennett, Gavin; Buckley, George; Ceska, Tom; Crabbe, Tom; Dale, Verity; Gowers, Lewis; Horsley, Helen; James, Lynwen; Jenkins, Kerry; Crepy, Karen; Kulisa, Claire; Lightfoot, Helen; Lock, Chris; Mack, Stephen; Morgan, Trevor; Nicolas, Anne-Lise; Pitt, Will; Sabin, Verity; Wright, Sara Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 16 p. 4700 - 4704

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被引用次数: 21

摘要

Download PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... The SAR and pharmacokinetic profiles of a series of multi-isoform PI3K inhibitors based on a 3,4-dihydro-2H-benzo[1,4]oxazine scaffold are disclosed. ... The SAR and pharmacokinetic profiles of a series of multi-isoform PI3K inhibitors based on a 3,4-dihydro-2H-benzo[1,4]oxazine ...