Tetrahedron letters

Palladium-catalyzed ring expansion reaction of 1-alkynylcyclobutanols with aryl iodides: an efficient route to 2-disubstituted methylenecyclopentanones

LM Wei, LL Wei, WB Pan, MJ Wu

文献索引：Wei, Li-Mei; Wei, Li-Lan; Pan, Wen-Bin; Wu, Ming-Jung Tetrahedron Letters, 2003 , vol. 44, # 3 p. 595 - 597

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被引用次数: 18

摘要

The reaction of 1-alkynylcyclobutanols with aryl iodides in the presence of Pd (OAc) 2 and Et3N in acetonitrile at 80° C for 24 h gives 2-disubstituted methylenecyclopentan-1-ones in modest to good yields. The tandem insertion-ring expansion process proceeds via the