Tetrahedron letters

A versatile synthesis of tetraester polyamine lipids for gene transfection

ME Lizarzaburu, MJ Kurth, MH Nantz

文献索引：Lizarzaburu, Mike E.; Kurth, Mark J.; Nantz, Michael H. Tetrahedron Letters, 1999 , vol. 40, # 51 p. 8985 - 8988

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被引用次数: 6

摘要

The preparation of polyamine lipids via Michael addition of diamines to tetraester bisacrylates is described. A new pentaerythritol protection strategy enabled the synthesis of a bis (p-methoxybenzyl) diether diol which was used to prepare the saturated and unsaturated diester cores.