Novel chemoenzymatic methodology for the regioselective glycine loading on polyhydroxy compounds

…, M Calderón, AK Prasad, VS Parmar, R Haag

文献索引：Malhotra, Shashwat; Calderon, Marcelo; Prasad, Ashok K.; Parmar, Virinder S.; Haag, Rainer Organic and Biomolecular Chemistry, 2010 , vol. 8, # 9 p. 2228 - 2237

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被引用次数: 12

摘要

In the present work, we have developed a highly efficient temperature-dependent chemo- enzymatic methodology for the regioselective synthesis of novel esters of glycerol, G1 tri- glycerol dendrons and related esters for the first time using 4-nitrophenyl 2-(tert- butoxycarbonyl) acetate (Boc-gly-Ph-pNO2)(2) as the acylating agent. This methodology offers efficient and controlled loading of amino acid (glycine) on polyhydroxy compounds.