Structure-based design of novel class II c-Met inhibitors: 1. Identification of pyrazolone-based derivatives

MH Norman, L Liu, M Lee, N Xi, I Fellows…

文献索引：Menezes, Royce; Smith, Michael B. Synthetic Communications, 1988 , vol. 18, # 4 p. 1625 - 1636

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被引用次数: 40

摘要

... Volume: Page ... For the preparation of the isomeric pyrrolidinone derivative 21, tert-butyl 2-oxopyrrolidine-1-carboxylate, 18, was first alkylated with benzyl bromide(14 ... a Reagents: (a) LDA, THF, −78 °C → 0 °C, BnBr; (b) TFA, DCM 0 °C, NaOH, rt; (c) 4-nitrophenyl ...