Thiol-Activated DNA Damage by α-Bromo-2-cyclopentenone

…, H Zang, C Huang, M Harmata, P Brown…

文献索引：Fekry, Mostafa I.; Price, Nathan E.; Zang, Hong; Huang, Chaofeng; Harmata, Michael; Brown, Paul; Daniels, J. Scott; Gates, Kent S. Chemical Research in Toxicology, 2011 , vol. 24, # 2 p. 217 - 228

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被引用次数: 11

摘要

Some biologically active chemicals are relatively stable in the extracellular environment but, upon entering the cell, undergo biotransformation into reactive intermediates that covalently modify DNA. The diverse chemical reactions involved in the bioactivation of DNA-damaging agents are both fundamentally interesting and of practical importance in medicinal chemistry and toxicology. The work described here examines the bioactivation of α-haloacrolyl- ...