Synthesis and biological evaluation of new curcumin derivatives as antioxidant and antitumor agents

…, MB El-Ashmawy, MNA Nasr, MA El-Sherbeny…

文献索引：Bayomi, Said M.; El-Kashef, Hassan A.; El-Ashmawy, Mahmoud B.; Nasr, Magda N. A.; El-Sherbeny, Magda A.; Badria, Farid A.; Abou-Zeid, Laila A.; Ghaly, Mariam A.; Abdel-Aziz, Naglaa I. Medicinal Chemistry Research, 2013 , vol. 22, # 3 p. 1147 - 1162

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被引用次数: 23

摘要

Abstract Twenty-four new compounds were prepared, taking curcumin as a lead, in order to explore their antioxidant and antitumor properties. The capacities of these derivatives to scavenge the 2, 2′-azinobis (3-ethylbenzothiazoline-6-sulfonic acid) radical cation (ABTS.+), and to protect human red blood cells (RBCs) from oxidative haemolysis were investigated. In addition, the percentage viability of different cell lines (Hep G2, WI38, ...