Analogs of phenothiazines. 3. Synthesis and potential antidepressant activity of some phenothiazine derivatives and related compounds containing a carbocyclic …

C Kaiser, DH Tedeschi, PJ Fowler…

文献索引：Kaiser,C. et al. Journal of Medicinal Chemistry, 1971 , vol. 14, p. 179 - 186

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被引用次数: 9

摘要

1970 trans-2-(2-Chloro-lO-phenothiaainyl)-N, N-dimethylcyclopropanemethylamine (I), a side chain modified analog of chlorpromazine, was prepared and found to have potent antidepressant activity in animals. Synthesis and pharmacological study of 34 analogs and derivatives of 1 are reported. Formation of rearranged products upon alkylation of several diphenylmethane derivatives with 2-bromo-N, N-dimethylcyclopropanecarboxamide and ...