Preparation of 13-Substituted 8H-Dibenzo [a, g] quinolizin-8-ones by Intramolecular Wittig-Horner Reaction of Dialkyl 2-(o-Acylbenzoyl)-1, 2-dihydro-1- …

K Akiba, Y Negishi, N Inamoto

文献索引：Akiba, Kin-ya; Negishi, Yoshio; Inamoto, Naoki Bulletin of the Chemical Society of Japan, 1984 , vol. 57, # 8 p. 2188 - 2192

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被引用次数: 5

摘要

Dialkyl 2-(o-acylbenzoyl)-1, 2-dihydro-1-isoquinolyl-phosphonates (1) were prepared by reactions of isoquinoline, o-acylbenzoyl chloride, and trialkyl phosphites. Treatment of 1 with lithium diisopropylamide gave 13-substituted 8H-dibenzo [a, g] quinolizin-8-ones by intramolecular Wittig-Horner reaction. Especially, 13-alkoxy and dimethylamino derivatives were obtained in good yields. A similar reaction of dimethyl 1-[o-(methoxycarbonyl) ...