Identification and synthesis of major metabolites of Vasopressin V 2-receptor agonist WAY-151932, and antagonist, Lixivaptan®

…, EJ Trybulski, J Bagli, S Croce, J Considine, J Qi…

文献索引：Molinari, Albert J.; Trybulski, Eugene J.; Bagli, Jehan; Croce, Susan; Considine, John; Qi, Jian; Ali, Kadum; DeMaio, William; Lihotz, Lynne; Cochran, David Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 21 p. 5796 - 5800

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被引用次数: 4

摘要

Small molecule agonists and antagonists of the V2-vasopressin receptor have been discovered and have undergone clinical trials. In conjunction with these discovery programs, the synthesis and biological testing of various metabolites associated with these clinical targets were actively pursued. We now report the results of our synthetic efforts and the corresponding biological data generated for several of the metabolites of WAY-151932 ...