Relationship between protective effect of xanthone on endothelial cells and endogenous nitric oxide synthase inhibitors

DJ Jiang, GY Hu, JL Jiang, HL Xiang, HW Deng…

文献索引：Jiang, De-Jian; Hu, Gao-Yun; Jiang, Jun-Lin; Xiang, Hong-Lin; Deng, Han-Wu; Li, Yuan-Jian Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 23 p. 5171 - 5177

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被引用次数: 41

摘要

1, 3, 5, 6-tetrahydroxyxanthone was synthesized. The relationship between protective effect of xanthone on endothelial cells and endogenous nitric oxide synthase inhibitors was investigated. Endothelial cells were treated with ox-LDL (100 μg/mL) for 48 h. Adhesion of monocytes to endothelial cells and release of lactate dehydrogenase (LDH) was determined. Levels of tumor necrosis factor-α (TNF-α), monocyte chemoattractant protein- ...