Intervention in cyclophosphamide induced oxidative stress and DNA damage by a flavonyl-thiazolidinedione based organoselenocyanate and evaluation of its …

SS Roy, P Chakraborty, S Bhattacharya

文献索引：Roy, Somnath Singha; Chakraborty, Pramita; Bhattacharya, Sudin European Journal of Medicinal Chemistry, 2014 , vol. 73, p. 195 - 209

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被引用次数: 12

摘要

Abstract A novel flavonyl-thiazolidinedione based organoselenocyanate compound was synthesized and established as nontoxic at the doses of 2.5 and 5 mg/kg bw in mice. Oral administration of the compound in combination with cyclophosphamide (CP) resulted in an improved therapeutic efficacy which was mostly evidenced in terms of tumor burden and protection of normal cells. The adjuvant therapy was proved to be immensely significant in ...