Synthesis and antifungal activity of 6-arylamino-phthalazine-5, 8-diones and 6, 7-bis (arylthio)-phthalazine-5, 8-diones

CK Ryu, RE Park, MY Ma, JH Nho

文献索引：Ryu, Chung-Kyu; Park, Rae-Eun; Ma, Mi-Young; Nho, Ji-Hee Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 9 p. 2577 - 2580

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被引用次数: 90

摘要

6-Arylamino-phthalazine-5, 8-diones and 6, 7-bis (arylthio)-phthalazine-5, 8-diones were synthesized and tested for in vitro antifungal activity against two pathogenic strains of fungi. Among those tested, many compounds showed good antifungal activity. The results suggest that phthalazine-5, 8-diones would be potent antifungal agents.