... NG7 2RD UK. Robert J. Blade. Department of Pesticide Research, Wellcome Research Laboratories, Ravens Lane, Berkhamsted, Herts, HP4 2DY, UK. Received 22 July 1987, Available online 9 March 2001. Abstract. Hydrometallation of α,ω-diynes is used to make ω-acetylenic isobutylamide synthons: new syntheses of anacyclin, pellitorine and its vinylogous triene are described. ... References. 1; a L. Crombie, D. Fisher; Tetrahedron Lett. (1985), p. 2477. ...