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举例 :可输入Filippa Pettersson 或者 Cancer Res. 75(6) , 1102-12, (2015) 或者10.1002/anie.201600521

Helvetica chimica acta

Silicon??Directed Nazarov Reactions II. Preparation and Cyclization of β??Silyl??substituted Divinyl Ketones

TK Jones, SE Denmark

文献索引：Jones, Todd K.; Denmark, Scott E. Helvetica Chimica Acta, 1983 , vol. 66, # 8 p. 2377 - 2396

全文：HTML全文

被引用次数: 91

摘要

Abstract Two general methods for the preparation of β-silyl-substituted divinyl ketones have been developed starting from either α, β-unsaturated aldehydes or simple ketones. Anhydrous FeCl 3 induces the cyclization to cyclopentenones under mild conditions and in good yields with predictable and complete control over the position of the double bond in the five-membered ring. The observed effects of substituents on rate can be explained by a ...

4-methyl-1-trimethylsilylpenta-1,4-dien-3-ol结构式

4-methyl-1-trim...

~75%

4-methyl-1-trimethylsilylpenta-1,4-dien-3-one结构式

4-methyl-1-trim...

2-溴乙烯基三甲基硅烷结构式

2-溴乙烯基三甲基硅烷

~%

4-methyl-1-trimethylsilylpenta-1,4-dien-3-one结构式

4-methyl-1-trim...

4-methyl-1-trimethylsilylhexa-1,4-dien-3-ol结构式

4-methyl-1-trim...

~92%

4-methyl-1-trimethylsilylhexa-1,4-dien-3-one结构式

4-methyl-1-trim...

2-溴乙烯基三甲基硅烷结构式

2-溴乙烯基三甲基硅烷

~%

4-methyl-1-trimethylsilylhexa-1,4-dien-3-one结构式

4-methyl-1-trim...

trans-3-(trimethylsilyl)acryl-aldehyde结构式

trans-3-(trimet...

~%

4-methyl-1-trimethylsilylhexa-1,4-dien-3-one结构式

4-methyl-1-trim...

1-phenyl-5-trimethylsilylpenta-1,4-dien-3-ol结构式

1-phenyl-5-trim...

~%

4-phenylcyclopent-2-en-1-one结构式

4-phenylcyclope...

2-溴乙烯基三甲基硅烷结构式

2-溴乙烯基三甲基硅烷

~%

1-(3-methylcyclohexen-1-yl)-3-trimethylsilylprop-2-en-1-one结构式

1-(3-methylcycl...

(9ci)-3-甲基-1-环己烯-1-羧醛结构式

(9ci)-3-甲基-1-环己...

~%

1-(3-methylcyclohexen-1-yl)-3-trimethylsilylprop-2-en-1-one结构式

1-(3-methylcycl...

1-(cyclohexen-1-yl)prop-2-en-1-one结构式

1-(cyclohexen-1...

~%

2,3,3a,4,5,6-Hexahydro-(1H)-inden-1-one结构式

2,3,3a,4,5,6-He...

2,3,4,5,6,7-Hexahydro-1H-indene-1-one结构式

2,3,4,5,6,7-Hex...

1-(Cyclohex-1-enyl)prop-2-en-1-ol结构式

1-(Cyclohex-1-e...

~%

2,3,4,5,6,7-Hexahydro-1H-indene-1-one结构式

2,3,4,5,6,7-Hex...

1-环己烯-1-甲醛结构式

1-环己烯-1-甲醛

~%

2,3,4,5,6,7-Hexahydro-1H-indene-1-one结构式

2,3,4,5,6,7-Hex...

2-丁烯醛结构式

2-溴乙烯基三甲基硅烷结构式

2-溴乙烯基三甲基硅烷

~%

1-trimethylsilylhexa-1,4-dien-3-ol结构式

1-trimethylsily...

(E)-1-(3,4-dihydro-1-naphthyl)-3-trimethylsilyl-2-propen-1-ol结构式

(E)-1-(3,4-dihy...

~90%

1-naphthalen-1-yl-3-trimethylsilylprop-2-en-1-one结构式

1-naphthalen-1-...

trans-3-(trimethylsilyl)acryl-aldehyde结构式

trans-3-(trimet...

~%

1-naphthalen-1-yl-3-trimethylsilylprop-2-en-1-one结构式

1-naphthalen-1-...

1-tetralone (2,4,6-triisopropylbenzenesulfonyl)hydrazone结构式

1-tetralone (2,...

~%

1-naphthalen-1-yl-3-trimethylsilylprop-2-en-1-one结构式

1-naphthalen-1-...

1-四氢萘酮结构式

~%

1-naphthalen-1-yl-3-trimethylsilylprop-2-en-1-one结构式

1-naphthalen-1-...

trans-3-(trimethylsilyl)acryl-aldehyde结构式

trans-3-(trimet...

~%

1-(6-methylcyclohexen-1-yl)-3-trimethylsilylprop-2-en-1-one结构式

1-(6-methylcycl...

2-methylcyclohexanone (2,4,6-triisopropylphenyl)sulphonylhydrazone结构式

2-methylcyclohe...

~%

1-(6-methylcyclohexen-1-yl)-3-trimethylsilylprop-2-en-1-one结构式

1-(6-methylcycl...

2-甲基环己酮结构式

2-甲基环己酮

~%

1-(6-methylcyclohexen-1-yl)-3-trimethylsilylprop-2-en-1-one结构式

1-(6-methylcycl...

1-(Cyclohex-1-enyl)prop-2-en-1-ol结构式

1-(Cyclohex-1-e...

~42%

1-(cyclohexen-1-yl)prop-2-en-1-one结构式

1-(cyclohexen-1...

1-环己烯-1-甲醛结构式

1-环己烯-1-甲醛

~%

1-(cyclohexen-1-yl)prop-2-en-1-one结构式

1-(cyclohexen-1...

3-戊酮结构式

~%

4-ethyl-1-trimethylsilylhexa-1,4-dien-3-ol结构式

4-ethyl-1-trime...

trans-3-(trimethylsilyl)acryl-aldehyde结构式

trans-3-(trimet...

3-pentanone (2,4,6-triisopropylbenzenesulfonyl)hydrazone结构式

3-pentanone (2,...

~%

4-ethyl-1-trimethylsilylhexa-1,4-dien-3-ol结构式

4-ethyl-1-trime...

频那酮结构式

~%

5,5-dimethyl-4-methylidene-1-trimethylsilylhex-1-en-3-ol结构式

5,5-dimethyl-4-...

4-methylidene-1-trimethylsilylhex-1-en-3-one结构式

4-methylidene-1...

~49%

5-ethylcyclopent-2-en-1-one结构式

5-ethylcyclopen...

4-methylidene-1-trimethylsilylhex-1-en-3-ol结构式

4-methylidene-1...

~%

5-ethylcyclopent-2-en-1-one结构式

5-ethylcyclopen...

2-甲基丙烯醛结构式

2-甲基丙烯醛

2-溴乙烯基三甲基硅烷结构式

2-溴乙烯基三甲基硅烷

~%

4-methyl-1-trimethylsilylpenta-1,4-dien-3-ol结构式

4-methyl-1-trim...

反-2-甲基-2-丁烯醛结构式

反-2-甲基-2-丁烯醛

2-溴乙烯基三甲基硅烷结构式

2-溴乙烯基三甲基硅烷

~%

4-methyl-1-trimethylsilylhexa-1,4-dien-3-ol结构式

4-methyl-1-trim...

桂皮醛结构式

2-溴乙烯基三甲基硅烷结构式

2-溴乙烯基三甲基硅烷

~%

1-phenyl-5-trimethylsilylpenta-1,4-dien-3-ol结构式

1-phenyl-5-trim...

4-methylidene-1-trimethylsilylhex-1-en-3-ol结构式

4-methylidene-1...

~87%

4-methylidene-1-trimethylsilylhex-1-en-3-one结构式

4-methylidene-1...

trans-3-(trimethylsilyl)acryl-aldehyde结构式

trans-3-(trimet...

~%

4-methylidene-1-trimethylsilylhex-1-en-3-one结构式

4-methylidene-1...

1-trimethylsilylhexa-1,4-dien-3-ol结构式

1-trimethylsily...

~96%

1-trimethylsilylhexa-1,4-dien-3-one结构式

1-trimethylsily...

2-溴乙烯基三甲基硅烷结构式

2-溴乙烯基三甲基硅烷

~%

1-trimethylsilylhexa-1,4-dien-3-one结构式

1-trimethylsily...

1-naphthalen-1-yl-3-trimethylsilylprop-2-en-1-one结构式

1-naphthalen-1-...

~60%

2,3-二氢-1H-苯并[e]茚-1-酮结构式

2,3-二氢-1H-苯并[e]茚-1-酮

1-tetralone (2,4,6-triisopropylbenzenesulfonyl)hydrazone结构式

1-tetralone (2,...

~%

2,3-二氢-1H-苯并[e]茚-1-酮结构式

2,3-二氢-1H-苯并[e]茚-1-酮

1-四氢萘酮结构式

~%

2,3-二氢-1H-苯并[e]茚-1-酮结构式

2,3-二氢-1H-苯并[e]茚-1-酮

(E)-1-(3,4-dihydro-1-naphthyl)-3-trimethylsilyl-2-propen-1-ol结构式

(E)-1-(3,4-dihy...

~%

2,3-二氢-1H-苯并[e]茚-1-酮结构式

2,3-二氢-1H-苯并[e]茚-1-酮

(E)-1-(1-cyclopentenyl)-3-trimethylsilyl-2-propen-1-ol结构式

(E)-1-(1-cyclop...

~86%

1-(cyclopenten-1-yl)-3-trimethylsilylprop-2-en-1-one结构式

1-(cyclopenten-...

1-环戊烯甲醛结构式

1-环戊烯甲醛

~%

1-(cyclopenten-1-yl)-3-trimethylsilylprop-2-en-1-one结构式

1-(cyclopenten-...

2-溴乙烯基三甲基硅烷结构式

2-溴乙烯基三甲基硅烷

~%

1-(cyclopenten-1-yl)-3-trimethylsilylprop-2-en-1-one结构式

1-(cyclopenten-...

trans-3-(trimethylsilyl)acryl-aldehyde结构式

trans-3-(trimet...

~%

1-(cyclopenten-1-yl)-3-trimethylsilylprop-2-en-1-one结构式

1-(cyclopenten-...

环戊酮结构式

~%

1-(cyclopenten-1-yl)-3-trimethylsilylprop-2-en-1-one结构式

1-(cyclopenten-...

4-ethyl-1-trimethylsilylhexa-1,4-dien-3-ol结构式

4-ethyl-1-trime...

~92%

4-ethyl-1-trimethylsilylhexa-1,4-dien-3-one结构式

4-ethyl-1-trime...

3-pentanone (2,4,6-triisopropylbenzenesulfonyl)hydrazone结构式

3-pentanone (2,...

~%

4-ethyl-1-trimethylsilylhexa-1,4-dien-3-one结构式

4-ethyl-1-trime...

3-戊酮结构式

~%

4-ethyl-1-trimethylsilylhexa-1,4-dien-3-one结构式

4-ethyl-1-trime...

5,5-dimethyl-4-methylidene-1-trimethylsilylhex-1-en-3-ol结构式

5,5-dimethyl-4-...

~84%

5,5-dimethyl-4-methylidene-1-trimethylsilylhex-1-en-3-one结构式

5,5-dimethyl-4-...

频那酮结构式

~%

5,5-dimethyl-4-methylidene-1-trimethylsilylhex-1-en-3-one结构式

5,5-dimethyl-4-...

1-phenyl-5-trimethylsilylpenta-1,4-dien-3-ol结构式

1-phenyl-5-trim...

~90%

1-phenyl-5-trimethylsilylpenta-1,4-dien-3-one结构式

1-phenyl-5-trim...

2-溴乙烯基三甲基硅烷结构式

2-溴乙烯基三甲基硅烷

~%

1-phenyl-5-trimethylsilylpenta-1,4-dien-3-one结构式

1-phenyl-5-trim...

cyclopentanone (2,4,6-triisopropylbenzenesulfonyl)hydrazone结构式

cyclopentanone ...

~%

1-(cyclopenten-1-yl)-3-trimethylsilylprop-2-en-1-one结构式

1-(cyclopenten-...

(E)-1-(1-cyclohexenyl)-3-trimethylsilyl-2-propen-1-ol结构式

(E)-1-(1-cycloh...

~86%

1-(cyclohexen-1-yl)-3-trimethylsilylprop-2-en-1-one结构式

1-(cyclohexen-1...

1-环己烯-1-甲醛结构式

1-环己烯-1-甲醛

~%

1-(cyclohexen-1-yl)-3-trimethylsilylprop-2-en-1-one结构式

1-(cyclohexen-1...

2-溴乙烯基三甲基硅烷结构式

2-溴乙烯基三甲基硅烷

~%

1-(cyclohexen-1-yl)-3-trimethylsilylprop-2-en-1-one结构式

1-(cyclohexen-1...

cyclohexanone 2,4,6-triisopropylbenzenesulfonyl hydrazone结构式

cyclohexanone 2...

~%

1-(cyclohexen-1-yl)-3-trimethylsilylprop-2-en-1-one结构式

1-(cyclohexen-1...

环己酮结构式

~%

1-(cyclohexen-1-yl)-3-trimethylsilylprop-2-en-1-one结构式

1-(cyclohexen-1...