Journal of medicinal chemistry

Synthesis of 3, 4-dihydroxy-5-fluoro-DL-Phenylalanine and 3, 4-Dihydroxy-5-[fluorine-18] fluoro-DL-phenylalanine

G Firnau, C Nahmias, S Garnett

文献索引：Firnau,G. et al. Journal of Medicinal Chemistry, 1973 , vol. 16, p. 416 - 418

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被引用次数: 25

摘要

F 170 62b aQuantitative. bCalculated from 6. about two-thirds of lesions. Dihydroxyphenylalanine (DOPA) enters healthy, mature brain capillaries where it is decarboxylated to dopamine. Dopamine can be concentrated in the capillaries by an amine oxidase inhibitor and demonstrated by fluoresence microscopy. Damaged or lmmature capillaries will not do this.'DOPA labeled with a suitable y-emitting isotope would, ...