Tetrahedron

Regioselective metallations of (methoxymethoxy) arenes

RC Ronald, MR Winkle

文献索引：Ronald, Robert C.; Winkle, Mark R. Tetrahedron, 1983 , vol. 39, # 12 p. 2031 - 2042

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被引用次数: 78

摘要

The methoxymethoxy substituent when attached to an aromatic ring functions as a moderately strong ortho-directing group in hydrogen-metal exchange reactions. In many cases the propensity of the methoxymethoxylated arene toward ring metallation is greatly enhanced with concomitant suppression of undesirable side reactions such as nucleophilic attack and addition of the metallating species. Unlike many other ortho-directing groups, ...