Abstract The reactions of 2, 3-dimethyl-(4), 2, 3-diphenyl-(6), and 2-methyl-3-phenyl- pyrazine monoxides (8 and 9) with phosphoryl chloride and acetic anhydride resulted in giving monochloro-and monacetoxy-pyrazines in almost all cases. However, the reaction of 6 with acetic anhydride afforded exceptionally a diacetoxydihydro-pyrazine. These products were converted further to hydroxy or dichloro derivatives.