A new and convenient synthesis of N??substituted perhydroazepines from adipaldehyde and primary amines with tetracarbonylhydridoferrate, HFe (CO) 4−, as a …

SC Shim, CH Doh, TJ Kim, HK Lee…

文献索引：Shim, Sang Chul; Doh, Chil Hoon; Kim, Tae Jeong; Lee, Hak Ki; Kim, Ki Doo Journal of Heterocyclic Chemistry, 1988 , vol. 25, p. 1383 - 1385

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被引用次数: 11

摘要

Abstract Ethanolic tetracarbonylhydridoferrate combined with adipaldehyde is very efficient for the selective transformation of an amino group into perhydroazepine. A large variety of both aliphatic and aromatic amines react with adipaldehyde in the presence of tetracarbonylhydridoferrate at room temperature and carbon monoxide to give the corresponding N-alkyl-and N-arylperhydroazepines in good to excellent yields.