Syntheses of 3, 3-dimethyl-2-hydroxybutyric acid and tertiary leucine and their optical resolutions

T Tanabe, S Yajima, M Imaida

文献索引：Tanabe,T. et al. Bulletin of the Chemical Society of Japan, 1968 , vol. 41, p. 2178 - 2179

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被引用次数: 15

摘要

DL-3, 3-Dimethyl-2-hydroxybutyric acid (I) was prepared by the reduction of trimethylpyruvic acid (II) with sodium amalgam1) and by catalytic hydrogenation with palladium black. 2'The optical resolution of I has not yet been attempted, however. DL-t-Leucine (III) was prepared by the reduction of trimethylpyruvic acid oxime8'and resolved into its optical isomers by the treatment of the N-formyl derivative of III with brucine. 4) The absolute configuration of the ( ...