Design and synthesis of phthalimide-type histone deacetylase inhibitors

…, S Maeda, M Yoshida, Y Hashimoto, H Miyachi

文献索引：Shinji, Chihiro; Nakamura, Takanori; Maeda, Satoko; Yoshida, Minoru; Hashimoto, Yuichi; Miyachi, Hiroyuki Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 20 p. 4427 - 4431

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被引用次数: 50

摘要

Several hydroxamic acid derivatives with a substituted phthalimide group as a linker and/or cap structure, prepared during structural development studies based on thalidomide, were found to have histone deacetylase (HDAC)-inhibitory activity. Structure–activity relationship studies indicated that nature of the substituent introduced at the phthalimide nitrogen atom, introduction of a hydroxamic acid structure, and distance between the N-hydroxyl group ...