Cyclization of ortho-halogenated N-acylbenzylamines: A formal synthesis of (±)-cherylline

SV Kessar, P Singh, R Chawla, P Kumar

文献索引：Kessar, Satinder V.; Singh, Paramjit; Chawla, Ravinder; Kumar, Pawan Journal of the Chemical Society, Chemical Communications, 1981 , # 20 p. 1074 - 1075

全文：HTML全文

被引用次数: 16

摘要

ortho-Halogenated N-alkyl-N-acylbenzylamines can be cyclised to dihydroisoquinolones by reaction with KNH2 in liquid NH3 or lithium di-isopropylamide in tetrahydrofuran under photolytic and thermal conditions; the procedure has been employed to synthesize (±)- cherylline.