Molecular features associated with polyamine modulation of NMDA receptors

…, L Fudala, H Navarro, LM Zhou, P Popik…

文献索引：Lewin, Anita H.; Fudala, Louise; Navarro, Hernan; Zhou, Li-Ming; Popik, Piotr; Faynsteyn, Alexander; Skolnick, Phil Journal of Medicinal Chemistry, 1998 , vol. 41, # 6 p. 988 - 995

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被引用次数: 22

摘要

The effect of 1, 3-diamines on basal and spermine-stimulated [3H] MK-801 binding was investigated. Systematic variations in the molecular parameters revealed that, in general, lipophilic 1, 3-diamines inhibited and hydrophilic 1, 3-diamines enhanced [3H] MK-801 binding in the nominal absence of glutamate and glycine. Furthermore, 1, 3-diamines which were highly monoprotonated at physiologic pH were more effective in modulating basal ...