Design and synthesis of a simplified inhibitor for XIAP-BIR3 domain

FRP Crisóstomo, Y Feng, X Zhu, K Welsh, J An…

文献索引：Pinacho Crisostomo, Fernando R.; Feng, Yongmei; Zhu, Xuejun; Welsh, Kate; An, Jing; Reed, John C.; Huang, Ziwei Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 22 p. 6413 - 6418

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被引用次数: 8

摘要

Based on tetrapeptide AVPI, we were able to design and synthesize a new simplified scaffold to inhibit the BIR3 domain of the XIAP protein at low micromolar range. The uncomplicated synthesis and the binding activity of the molecule disclosed here represent an attractive alternative to develop new compounds targeting the protein–protein interaction of XIAP/caspase9.