Synthesis and antiinflammatory activities of (. alpha.-cyclopropyl-p-tolyl) acetic acid and related compounds

G Rovnyak, PA Diassi, SD Levine…

文献索引：Rovnyak,G. et al. Journal of Medicinal Chemistry, 1973 , vol. 16, # 5 p. 487 - 490

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被引用次数: 6

摘要

The synthesis and antiinflammatory activities of (a-cyclopropyl-p-toly1) acetic acid (1) and related compounds are presented. The nature of the products formed during cyanide displacement reactions on a-bromo-p-tolyl cyclopropyl ketone (6) and p-(1-bromoethy1) phenyl cyclopropyl ketone (10) under a variety of conditions is described.