A photochromic agonist of AMPA receptors

P Stawski, M Sumser, D Trauner

文献索引：Stawski, Philipp; Sumser, Martin; Trauner, Dirk Angewandte Chemie - International Edition, 2012 , vol. 51, # 23 p. 5748 - 5751

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被引用次数: 38

摘要

Optochemical genetics uses small photoswitchable molecules to control neuronal activity. These can be attached covalently or noncovalently to their target proteins, which can be ligand or voltage-gated ion channels as well as G-protein coupled receptors. The integration of the resulting hybrid photoreceptors into excitable cells allows for the control of neural networks with the temporal and spatial precision that only light provides.[1]