Abstract A new neolignan designated (−)-maglifloenone and the known one futoenone, both of which contain the rarely occurring spirocyclohexadienone skeleton, have been isolated together with the tetrahydrofuranolignan (+)-veraguensin, an optically inactive tertiary base taspine and β-sitosterol from the leaves and twigs of Magnolia liliflora. The structure and stereochemistry of (−)-maglifloenone have been deduced from the spectral data and the ...