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举例 :可输入Filippa Pettersson 或者 Cancer Res. 75(6) , 1102-12, (2015) 或者10.1002/anie.201600521

. beta. 1-Selective adrenoceptor antagonists. 3. 4-Azolyl linked phenoxypropanolamines

…, LC Blaber, DT Burden, RA Melarange

文献索引：Machin, Peter J.; Hurst, David N.; Bradshaw, Rachel M.; Blaber, Leslie C.; Burden, David T.; Melarange, Rosemary A. Journal of Medicinal Chemistry, 1984 , vol. 27, # 4 p. 503 - 509

全文：HTML全文

被引用次数: 22

摘要

A series of 4-substituted phenoxypropanolamines has been prepared and examined for P- adrenoceptor activity. The 4-substituenta, di-and triazole ring systems connected to the phenoxy ring by different length chains, were chosen as a means of introducing cardioselectivity. This has been achieved, especially in the l-[4-[(4-chloropyrazol-lyl) methoxy] phenoxy]-3-(isopropylamino)-2-propanol (ll), the 4-[(2H-1, 2, 3-triazol-2-yl) ...

1-[2-(4-phenylmethoxyphenoxy)ethyl]-1,2,4-triazole结构式

1-[2-(4-phenylm...

~84%

4-[2-(1,2,4-triazol-1-yl)ethoxy]phenol结构式

4-[2-(1,2,4-tri...

1-苄氧基-4-(2-溴乙氧基)苯结构式

1-苄氧基-4-(2-溴乙氧基)苯

~%

4-[2-(1,2,4-triazol-1-yl)ethoxy]phenol结构式

4-[2-(1,2,4-tri...

4-羟基苯硫酚结构式

4-羟基苯硫酚

1-CHLOROMETHYL-1H-PYRAZOLE结构式

1-CHLOROMETHYL-...

~83%

4-(pyrazol-1-ylmethylsulfanyl)phenol结构式

4-(pyrazol-1-yl...

吡唑结构式

1-苄氧基-4-(2-溴乙氧基)苯结构式

1-苄氧基-4-(2-溴乙氧基)苯

~%

1-[2-(4-phenylmethoxyphenoxy)ethyl]pyrazole结构式

1-[2-(4-phenylm...

1-[3-(4-phenylmethoxyphenoxy)propyl]pyrazole结构式

1-[3-(4-phenylm...

~61%

4-(3-pyrazol-1-ylpropoxy)phenol结构式

4-(3-pyrazol-1-...

1-苄氧基-4-(3-溴丙氧基)苯结构式

1-苄氧基-4-(3-溴丙氧基)苯

~%

4-(3-pyrazol-1-ylpropoxy)phenol结构式

4-(3-pyrazol-1-...

1-[3-(4-phenylmethoxyphenoxy)propyl]-1,2,4-triazole结构式

1-[3-(4-phenylm...

~62%

4-[3-(1,2,4-triazol-1-yl)propoxy]phenol结构式

4-[3-(1,2,4-tri...

1-苄氧基-4-(3-溴丙氧基)苯结构式

1-苄氧基-4-(3-溴丙氧基)苯

~%

4-[3-(1,2,4-triazol-1-yl)propoxy]phenol结构式

4-[3-(1,2,4-tri...

4-phenyl-1-[2-(4-phenylmethoxyphenoxy)ethyl]pyrazole结构式

4-phenyl-1-[2-(...

~83%

4-[2-(4-phenylpyrazol-1-yl)ethoxy]phenol结构式

4-[2-(4-phenylp...

4-苯基-1H-吡唑结构式

4-苯基-1H-吡唑

~%

4-[2-(4-phenylpyrazol-1-yl)ethoxy]phenol结构式

4-[2-(4-phenylp...

1-苄氧基-4-(2-溴乙氧基)苯结构式

1-苄氧基-4-(2-溴乙氧基)苯

~%

4-[2-(4-phenylpyrazol-1-yl)ethoxy]phenol结构式

4-[2-(4-phenylp...

吲唑结构式

1-苄氧基-4-(2-溴乙氧基)苯结构式

1-苄氧基-4-(2-溴乙氧基)苯

~%

2-[2-(4-phenylmethoxyphenoxy)ethyl]indazole结构式

2-[2-(4-phenylm...

1-[2-(4-phenylmethoxyphenoxy)ethyl]indazole结构式

1-[2-(4-phenylm...

三氮唑结构式

1-苄氧基-4-(2-溴乙氧基)苯结构式

1-苄氧基-4-(2-溴乙氧基)苯

~%

2-[2-(4-phenylmethoxyphenoxy)ethyl]triazole结构式

2-[2-(4-phenylm...

1-[2-(4-phenylmethoxyphenoxy)ethyl]triazole结构式

1-[2-(4-phenylm...

1,2,4-三氮唑结构式

1,2,4-三氮唑

1-苄氧基-4-(2-甲烷磺酰氧基乙基)苯结构式

1-苄氧基-4-(2-甲烷磺酰...

~%

1-[2-(4-phenylmethoxyphenyl)ethyl]-1,2,4-triazole结构式

1-[2-(4-phenylm...

吡唑结构式

1-苄氧基-4-(2-甲烷磺酰氧基乙基)苯结构式

1-苄氧基-4-(2-甲烷磺酰...

~%

1-[2-(4-phenylmethoxyphenyl)ethyl]pyrazole结构式

1-[2-(4-phenylm...

咪唑结构式

1-苄氧基-4-(2-甲烷磺酰氧基乙基)苯结构式

1-苄氧基-4-(2-甲烷磺酰...

~%

1-[2-(4-phenylmethoxyphenyl)ethyl]imidazole结构式

1-[2-(4-phenylm...

莫诺苯宗结构式

1-(chloromethyl)-1,2,3-triazole hydrochloride结构式

1-(chloromethyl...

~%

2-[(4-phenylmethoxyphenoxy)methyl]triazole结构式

2-[(4-phenylmet...

1-[(4-phenylmethoxyphenoxy)methyl]triazole结构式

1-[(4-phenylmet...

4-chloro-1-[2-(4-phenylmethoxyphenoxy)ethyl]pyrazole结构式

4-chloro-1-[2-(...

~53%

4-[2-(4-chloropyrazol-1-yl)ethoxy]phenol结构式

4-[2-(4-chlorop...

1-苄氧基-4-(2-溴乙氧基)苯结构式

1-苄氧基-4-(2-溴乙氧基)苯

~%

4-[2-(4-chloropyrazol-1-yl)ethoxy]phenol结构式

4-[2-(4-chlorop...

1-[2-(4-phenylmethoxyphenyl)ethyl]imidazole结构式

1-[2-(4-phenylm...

~75%

4-(2-imidazol-1-ylethyl)phenol结构式

4-(2-imidazol-1...

1-苄氧基-4-(2-甲烷磺酰氧基乙基)苯结构式

1-苄氧基-4-(2-甲烷磺酰...

~%

4-(2-imidazol-1-ylethyl)phenol结构式

4-(2-imidazol-1...

1-[2-(4-phenylmethoxyphenyl)ethyl]pyrazole结构式

1-[2-(4-phenylm...

~68%

4-(2-pyrazol-1-ylethyl)phenol结构式

4-(2-pyrazol-1-...

1-苄氧基-4-(2-甲烷磺酰氧基乙基)苯结构式

1-苄氧基-4-(2-甲烷磺酰...

~%

4-(2-pyrazol-1-ylethyl)phenol结构式

4-(2-pyrazol-1-...

4-苯基-1H-吡唑结构式

4-苯基-1H-吡唑

1-苄氧基-4-(2-溴乙氧基)苯结构式

1-苄氧基-4-(2-溴乙氧基)苯

~%

4-phenyl-1-[2-(4-phenylmethoxyphenoxy)ethyl]pyrazole结构式

4-phenyl-1-[2-(...

咪唑结构式

1-苄氧基-4-(2-溴乙氧基)苯结构式

1-苄氧基-4-(2-溴乙氧基)苯

~%

1-[2-(4-phenylmethoxyphenoxy)ethyl]imidazole结构式

1-[2-(4-phenylm...

苯并咪唑结构式

1-苄氧基-4-(2-溴乙氧基)苯结构式

1-苄氧基-4-(2-溴乙氧基)苯

~%

1-[2-(4-phenylmethoxyphenoxy)ethyl]benzimidazole结构式

1-[2-(4-phenylm...

1,2,4-三氮唑结构式

1,2,4-三氮唑

1-苄氧基-4-(2-溴乙氧基)苯结构式

1-苄氧基-4-(2-溴乙氧基)苯

~%

1-[2-(4-phenylmethoxyphenoxy)ethyl]-1,2,4-triazole结构式

1-[2-(4-phenylm...

莫诺苯宗结构式

1-(chloromethyl)-1,2,3-triazole hydrochloride结构式

1-(chloromethyl...

~%

2-[(4-phenylmethoxyphenoxy)methyl]triazole结构式

2-[(4-phenylmet...

1-[(4-phenylmethoxyphenoxy)methyl]triazole结构式

1-[(4-phenylmet...

1-[2-(4-phenylmethoxyphenoxy)ethyl]pyrazole结构式

1-[2-(4-phenylm...

~55%

4-(2-pyrazol-1-ylethoxy)phenol结构式

4-(2-pyrazol-1-...

1-苄氧基-4-(2-溴乙氧基)苯结构式

1-苄氧基-4-(2-溴乙氧基)苯

~%

4-(2-pyrazol-1-ylethoxy)phenol结构式

4-(2-pyrazol-1-...

1-[2-(4-phenylmethoxyphenoxy)ethyl]imidazole结构式

1-[2-(4-phenylm...

~96%

4-(2-imidazol-1-ylethoxy)phenol结构式

4-(2-imidazol-1...

1-苄氧基-4-(2-溴乙氧基)苯结构式

1-苄氧基-4-(2-溴乙氧基)苯

~%

4-(2-imidazol-1-ylethoxy)phenol结构式

4-(2-imidazol-1...

1-[2-(4-phenylmethoxyphenyl)ethyl]-1,2,4-triazole结构式

1-[2-(4-phenylm...

~82%

4-[2-(1,2,4-triazol-1-yl)ethyl]phenol结构式

4-[2-(1,2,4-tri...

1-苄氧基-4-(2-甲烷磺酰氧基乙基)苯结构式

1-苄氧基-4-(2-甲烷磺酰...

~%

4-[2-(1,2,4-triazol-1-yl)ethyl]phenol结构式

4-[2-(1,2,4-tri...

4-氯吡唑结构式

1-苄氧基-4-(2-溴乙氧基)苯结构式

1-苄氧基-4-(2-溴乙氧基)苯

~%

4-chloro-1-[2-(4-phenylmethoxyphenoxy)ethyl]pyrazole结构式

4-chloro-1-[2-(...

吲唑结构式

1-苄氧基-4-(2-溴乙氧基)苯结构式

1-苄氧基-4-(2-溴乙氧基)苯

~%

2-[2-(4-phenylmethoxyphenoxy)ethyl]indazole结构式

2-[2-(4-phenylm...

1-[2-(4-phenylmethoxyphenoxy)ethyl]indazole结构式

1-[2-(4-phenylm...

三氮唑结构式

1-苄氧基-4-(2-溴乙氧基)苯结构式

1-苄氧基-4-(2-溴乙氧基)苯

~%

2-[2-(4-phenylmethoxyphenoxy)ethyl]triazole结构式

2-[2-(4-phenylm...

1-[2-(4-phenylmethoxyphenoxy)ethyl]triazole结构式

1-[2-(4-phenylm...

吡唑结构式

3-(dimethylamino)-1-(4-phenylmethoxyphenyl)propan-1-one结构式

3-(dimethylamin...

~68%

1-(4-phenylmethoxyphenyl)-3-pyrazol-1-ylpropan-1-one结构式

1-(4-phenylmeth...

4-氯吡唑结构式

甲醛结构式

~74%

(4-chloropyrazol-1-yl)methanol结构式

(4-chloropyrazo...

吡唑结构式

对羟基苯甲醇结构式

对羟基苯甲醇

~46%

4-(1H-吡唑-1-甲基)苯酚结构式

4-(1H-吡唑-1-甲基)苯酚

(4-chloropyrazol-1-yl)methanol结构式

(4-chloropyrazo...

~%

1H-Pyrazole, 4-chloro-1-(chloromethyl)-结构式

1H-Pyrazole, 4-...

2-(1-吡唑基)乙醇结构式

2-(1-吡唑基)乙醇

~%

4-(2-pyrazol-1-ylethylsulfanyl)phenol结构式

4-(2-pyrazol-1-...

1-[2-(4-phenylmethoxyphenoxy)ethyl]indazole结构式

1-[2-(4-phenylm...

~58%

4-(2-indazol-1-ylethoxy)phenol结构式

4-(2-indazol-1-...

吲唑结构式

~%

4-(2-indazol-1-ylethoxy)phenol结构式

4-(2-indazol-1-...

1-苄氧基-4-(2-溴乙氧基)苯结构式

1-苄氧基-4-(2-溴乙氧基)苯

~%

4-(2-indazol-1-ylethoxy)phenol结构式

4-(2-indazol-1-...

2-[2-(4-phenylmethoxyphenoxy)ethyl]triazole结构式

2-[2-(4-phenylm...

~82%

4-[2-(triazol-2-yl)ethoxy]phenol结构式

4-[2-(triazol-2...

1-苄氧基-4-(2-溴乙氧基)苯结构式

1-苄氧基-4-(2-溴乙氧基)苯

~%

4-[2-(triazol-2-yl)ethoxy]phenol结构式

4-[2-(triazol-2...

1,2,4-三氮唑结构式

1,2,4-三氮唑

1-苄氧基-4-(3-溴丙氧基)苯结构式

1-苄氧基-4-(3-溴丙氧基)苯

~%

1-[3-(4-phenylmethoxyphenoxy)propyl]-1,2,4-triazole结构式

1-[3-(4-phenylm...

吡唑结构式

1-苄氧基-4-(3-溴丙氧基)苯结构式

1-苄氧基-4-(3-溴丙氧基)苯

~%

1-[3-(4-phenylmethoxyphenoxy)propyl]pyrazole结构式

1-[3-(4-phenylm...

2-[(4-phenylmethoxyphenoxy)methyl]triazole结构式

2-[(4-phenylmet...

~59%

4-(triazol-2-ylmethoxy)phenol结构式

4-(triazol-2-yl...

莫诺苯宗结构式

~%

4-(triazol-2-ylmethoxy)phenol结构式

4-(triazol-2-yl...

莫诺苯宗结构式

~%

4-(triazol-1-ylmethoxy)phenol结构式

4-(triazol-1-yl...

1-[2-(4-phenylmethoxyphenoxy)ethyl]benzimidazole结构式

1-[2-(4-phenylm...

~80%

4-[2-(benzimidazol-1-yl)ethoxy]phenol结构式

4-[2-(benzimida...

苯并咪唑结构式

~%

4-[2-(benzimidazol-1-yl)ethoxy]phenol结构式

4-[2-(benzimida...

1-苄氧基-4-(2-溴乙氧基)苯结构式

1-苄氧基-4-(2-溴乙氧基)苯

~%

4-[2-(benzimidazol-1-yl)ethoxy]phenol结构式

4-[2-(benzimida...

1-[(4-phenylmethoxyphenoxy)methyl]triazole结构式

1-[(4-phenylmet...

~88%

4-(triazol-1-ylmethoxy)phenol结构式

4-(triazol-1-yl...