… and prediction of hydrophobicity parameters for highly lipophilic compounds: Application of the HPLC column??switching technique to measurement of log P of …

…, K Hanasato, H Inaba, M Aono, A Ohta

文献索引：Yamagami, Chisako; Araki, Kozue; Ohnishi, Kyoko; Hanasato, Kaoru; Inaba, Haruko; Aono, Masahiro; Ohta, Akihiro Journal of Pharmaceutical Sciences, 1999 , vol. 88, # 12 p. 1299 - 1304

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被引用次数: 27

摘要

Abstract In the preparatory stage of structure–activity relationship (QSAR) studies of anti- platelet aggregant pyrazine derivatives, log P values (P: 1-octanol/water partition coefficient) of diarylpyrazines were measured by a newly developed HPLC column-switching technique. The system consists of two processes:(1) adsorption of the sample at the top end of a short precolumn, and then (2) quantifying the enriched analyte by a conventional analytical ...