Synthesis and antioxidant potential of novel synthetic benzophenone analogues

T Tzanova, M Gerova, O Petrov, M Karaivanova…

文献索引：Tzanova, Tzvetomira; Gerova, Mariana; Petrov, Ognyan; Karaivanova, Margarita; Bagrel, Denyse European Journal of Medicinal Chemistry, 2009 , vol. 44, # 6 p. 2724 - 2730

全文：HTML全文

被引用次数: 25

摘要

Considering that oxidative stress is strongly implicated in the toxicity of chemotherapy, much effort is focused on the research of diverse antioxidants as protective agents. An efficient synthesis of three novel benzophenones containing 1, 3-thiazol moiety (6a–c) is described. Their antioxidant power was evaluated in vitro and in three cell lines (the cancerous MCF7 and the non-cancerous hTERT-HME1 mammary cells, and the H9c2 cardiomyoblastic ...