Biochemistry

Structural basis of substrate recognition in human nicotinamide N-methyltransferase

Y Peng, D Sartini, V Pozzi, D Wilk, M Emanuelli…

文献索引：Peng, Yi; Sartini, Davide; Pozzi, Valentina; Wilk, Dennis; Emanuelli, Monica; Yee, Vivien C. Biochemistry, 2011 , vol. 50, # 36 p. 7800 - 7808

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被引用次数: 26

摘要

Nicotinamide N-methyltransferase (NNMT) catalyzes the N-methylation of nicotinamide, pyridines, and other analogues using S-adenosyl-l-methionine as donor. NNMT plays a significant role in the regulation of metabolic pathways and is expressed at markedly high levels in several kinds of cancers, presenting it as a potential molecular target for cancer therapy. We have determined the crystal structure of human NNMT as a ternary complex ...