A series of ring-substituted (ie, methoxy and bromo) 3, 4-dihydro-and 1, 2, 3, 4-tetrahydro-β- carbolines was examined at 5-HT2A and 5-HT2C serotonin receptors. Whereas most of the methoxy-substituted derivatives typically displayed affinities similar to their unsubstituted parents, certain (particularly 8-substituted) bromo derivatives displayed enhanced affinity. A binding profile was obtained for selected β-carbolines.
