Synthesis of NK109, an anticancer benzo [c] phenanthridine alkaloid

…, A Mashiba, K Ishikawa, T Yokotsuka

文献索引：Nakanishi, Takeshi; Suzuki, Masanobu; Mashiba, Akihiro; Ishikawa, Keizou; Yokotsuka, Takashi Journal of Organic Chemistry, 1998 , vol. 63, # 13 p. 4235 - 4239

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被引用次数: 75

摘要

A total synthesis of NK109 (7-hydroxy-8-methoxy-5-methyl-2, 3-methylenedioxybenzo [c] phenanthridinium hydrogensulfate dihydrate), an anticancer benzo [c] phenanthridine alkaloid, is reported. The primary structure of this compound was erroneously communicated in 1973 as fagaridine (from Fagara xanthoxyloides) which is the 8-hydroxy regioisomer. NK109 has not yet been isolated from a natural source and therefore can only be obtained ...