Efficient one-pot, three-component synthesis of a library of pyrrolo [1, 2-c] pyrimidine derivatives

E Georgescu, F Georgescu, MM Popa…

文献索引：Georgescu, Emilian; Georgescu, Florentina; Popa, Marcel M.; Draghici, Constantin; Tarko, Laszlo; Dumitrascu, Florea ACS Combinatorial Science, 2012 , vol. 14, # 2 p. 101 - 107

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被引用次数: 19

摘要

Herein is reported a simple and efficient one-pot three-component synthesis of pyrrolo [1, 2- c] pyrimidine derivatives starting from various substituted pyrimidines, 2- bromoacetophenones, and electron deficient alkynes in epoxides acting both as reaction medium and HBr scavanger. This method proved to be very lucrative and avoids formation of ylide inactivation products. The synthesis represents an environmentally benign ...