The synthesis of lactam analogues of fentanyl

IV Mićović, GM Roglić, MD Ivanović…

文献索引：Micovic, Ivan V.; Roglic, Goran M.; Ivanovic; Dosen-Micovic, Ljiljana; Kiricojevic, Vesna D.; Popovic, Jelena B. Journal of the Chemical Society - Perkin Transactions 1, 1996 , # 16 p. 2041 - 2050

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被引用次数: 24

摘要

Fentanyl, sufentanil and alfentanil are clinically widely used anaesthetics and are structurally related to drugs with entirely different pharmacological activity such as droperidol, loperamide and lorcainide, etc. Therefore, in order to test their pharmacological activity, lactam analogues of fentanyl, a novel class of compounds, have been synthesized. In the first step, various primary amines have been selectively added to 1 equiv. of α, β- ...