Il Farmaco

1-Aminocylopropane-1-carboxylic acid derivatives as ligands at the glycine-binding site of the N-methyl-D-aspartate receptor

C Balsamini, A Bedini, G Spadoni, G Tarzia, A Tontini…

文献索引：Balsamini, Cesarino; Bedini, Annalida; Spadoni, Gilberto; Tarzia, Giorgio; Tontini, Andrea; Balduini, Walter; Cimino, Mauro Farmaco, 1998 , vol. 53, # 3 p. 181 - 188

全文：HTML全文

被引用次数: 9

摘要

Several 1-aminocyclopropane-1-carboxylic acid derivatives were prepared and tested for activity at the glycine-binding site of the N-methyl-D-aspartate (NMDA) receptor complex. Structural modifications involved the amino group, the carboxylic function or position 2 of the ring. When tested in a [3H]-MK-801 binding assay in the presence of glutamic acid, some of the compounds were able to activate the receptor. Two of them (3e and 6) are selective ...