Development of scalable syntheses of selective PI3K inhibitors

Q Huang, PF Richardson, NW Sach, J Zhu…

文献索引：Yu, Shen-Yi; Cai, Ya-Xian Synthetic Communications, 2003 , vol. 33, # 22 p. 3989 - 3995

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被引用次数: 29

摘要

... Volume: Page ... Eventually, we found the following conditions to be effective for all substrates: 1.2 equiv boronic acid, 5 mol % Pd(P t Bu 3 ) 2 , 1.2 equiv CsF ... was reacidified to pH 5 with 1 N HCl(20) and filtered to afford 3 directly in 86% yield on 50-g scale.(21, 22). ...