Tetrahedron letters

Isoprenoid biosynthesis via the methylerythritol phosphate pathway.(E)-4-Hydroxy-3-methylbut-2-enyl diphosphate: chemical synthesis and formation from …

…, M Seemann, C Grosdemange-Billiard, D Tritsch…

文献索引：Wolff, Murielle; Seemann, Myriam; Grosdemange-Billiard, Catherine; Tritsch, Denis; Campos, Narciso; Rodriguez-Concepcion, Manuel; Boronat, Albert; Rohmer, Michel Tetrahedron Letters, 2002 , vol. 43, # 14 p. 2555 - 2559

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被引用次数: 76

摘要

2-C-Methyl-d-erythritol cyclodiphosphate is converted into (E)-4-hydroxy-3-methylbut-2-enyl diphosphate by a cell-free system from an Escherichiacoli strain overexpressing the gcpE gene. The latter diphosphate, representing probably the last intermediate in the MEP pathway for isoprenoid biosynthesis, was identified by comparison with reference material obtained by chemical synthesis.