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Synthesis and antimicrobial activities of some new triazolothiadiazoles bearing 4-methylthiobenzyl moiety

DJ Prasad, M Ashok, P Karegoudar, B Poojary…

文献索引:Prasad, D. Jagadeesh; Ashok, Mithun; Karegoudar, Prakash; Poojary, Boja; Holla, B. Shivarama; Kumari, Nalilu Sucheta European Journal of Medicinal Chemistry, 2009 , vol. 44, # 2 p. 551 - 557

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被引用次数: 79

摘要

A series of substituted triazolothiadiazoles (6a–j and 7a–j) have been synthesized by condensing 4-amino-3-[4-methylthiobenzyl]-4H-1, 2, 4-triazole-5-thiol (5) with substituted aryl furoic acids/aromatic acids in the presence of POCl3. The triazole (5) was obtained by the fusion of 4-methylthiophenyl acetic acid (4) with thiocarbohydrazide. The structures of newly synthesized compounds are characterized by elemental analysis, IR, 1H NMR and ...