Molecular modelling studies suggested the synthesis of cis-1, 3, 4, 6, 7, 11b-hexahydro-2- methyl-7-phenyl-2H-pyrazino [2, 1-a] isoquinoline (7a) as a rigid analogue of the atypical antidepressant mianserin. Acylation of 2, 2-diphenylethylamine with chloroacetyl chloride gives the chloroacetamide (2). Cyclization of 2 with Pz06 in xylene provides l-(chloromethyl)- 3, 4-dihydro-4-phenylisoquinoline (3). Amination of 3, followed by reduction, gives the ...
