Synthesis and antiarrhythmic and parasympatholytic properties of substituted phenols. 2. Amides

DM Stout, WL Matier, C Barcelon-Yang…

文献索引：Stout, David M.; Matier, W. L.; Barcelon-Yang, Cynthia; Reynolds, Robert D.; Brown, Barry S. Journal of Medicinal Chemistry, 1984 , vol. 27, # 10 p. 1347 - 1350

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被引用次数: 14

摘要

The goal of our research has been to use the changrolin structure as a starting point in the hope that modifications to the molecule will result in a potent antiarrhythmic agent possessing few undesirable side effects. Our initial report described several heteroarylamine derivatives that had varying degrees of antiarrhythmic and parasympatholytic activities.'We found that the bis (pyrrolidinylmethy1)-phenol moiety in ...