Synthesis and immunosuppressive activity of new artemisinin derivatives. Part 2: 2-[12 (β or α)-Dihydroartemisinoxymethyl (or 1′-ethyl)] phenoxyl propionic acids and …

ZS Yang, JX Wang, Y Zhou, JP Zuo, Y Li

文献索引：Yang, Zhong-Shun; Wang, Jun-Xia; Zhou, Yu; Zuo, Jian-Ping; Li, Ying Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 23 p. 8043 - 8049

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被引用次数: 34

摘要

Another series of novel dihydroartemisinin derivatives were synthesized and assessed for their cytotoxicity of lymphocyte, inhibitory activity on mitogen-induced spleen lymphocyte proliferation in vitro. Some of the compounds exhibited inhibitory effects on ConA-induced T cell and LPS-induced B cell proliferation comparable to or more potent than parent artemisinin.