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Development of CINPA1 analogs as novel and potent inverse agonists of constitutive androstane receptor

W Lin, L Yang, SC Chai, Y Lu, T Chen

文献索引:Wunderlich; Stark; Carstens; Lohmann; Grizenko; Skoldinov Pharmazie, 1985 , vol. 40, # 12 p. 827 - 830

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被引用次数: 3

摘要

... Volume 108, 27 January 2016, Pages 505–528. ... CAR has two main structural domains, the DNA-binding domain (DBD) and the ligand-binding domain (LBD) [12], which are ... effects against both CAR and PXR [29], but only when very high concentrations (ie, at 20 or 40 μM) were ...