Synthesis of a functionalized oxabicyclo [2.2. 1]-heptene-based chemical library

…, E Bolstad, SC Bergmeier, MC McMills…

文献索引：Luesse, Sarah B.; Wells, Gregg; Miller, Jeanne; Bolstad, Erin; Bergmeier, Stephen C.; McMills, Mark C.; Priestley, Nigel D.; Wright, Dennis L. Combinatorial Chemistry and High Throughput Screening, 2012 , vol. 15, # 1 p. 81 - 89

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被引用次数: 4

摘要

The 7-oxabicyclo [2.2. 1] heptene ring system is a common structural motif in many pharmacologically interesting molecules. We recognized the potential to employ this highly oxygenated and conformationally-restricted scaffold in diversity-oriented synthesis to generate a library of non-chiral but topologically complex compounds. Herein, we report the synthesis and biological evaluation of two 96-member tricyclic libraries containing the ...